The Academic Press has just released the third edition of our classic textbook, The Principles of Gender-Specific Medicine: Gender in the Genomic Era. We published the first overview of what was then the new science of gender-specific medicine in 2004. The second edition was published in 2010. Since the publication of these works, gender-specific medicine has become firmly established and is the focus of basic science and clinical investigation worldwide. This edition reflects the scientific revolution of the 21st century and is a complete departure from the format of the first two editions of our textbook. Its contents showcase the innovative and cutting-edge technology of the genomic era as well as the potential power of synthetic biology and the increasing use of engineering to augment the performance of living beings.

Praise for Principles of Gender-Specific Medicine, 3^rd edition

As much as the first edition of Principles of Gender-Specific Medicine defined the field of sex and gender health a decade ago, this third edition redefines it taking into account the evolution and complexity of genomic, hormonal and immunological science of sex differences.  Marianne Legato uses an innovative approach to organizing cutting edge topics outside of the typical format of medical textbooks, which aids the reader in viewing the science in novel ways.  Even for those working in the field of sex and gender based medicine, there is so much to learn from this rich collection of experts and content. Thank you once again Marianne Legato!

Alyson J. McGregor, MD, MA, FACEP
Director, Division of Sex and Gender in Emergency Medicine (SGEM)
Director, Sex and Gender in Emergency Medicine (SGEM) Fellowship
Associate Professor of Emergency Medicine
Warren Alpert Medical School of Brown University

The name Marianne Legato has become almost synonymous with Gender and Sex-specific Medicine. She was founder and Editor-in Chief of the first scientific journal dedicated to this new science (and has recently founded a new journal – “Gender and the Genome”). She was and is Editor-in-Chief of the first textbook on Gender Medicine, which appears now in the present third edition and she has been a scout in promoting Gender Medicine throughout the world. Her books have been eye-openers for many of us and this new edition of Principles of Gender-Specific Medicine is again a breakthrough. It includes carefully chosen contributions from leading scholars, researchers and clinicians from all over the globe, who present the state-of-the-art in their respective fields. What “The Harrison” is for Internal Medicine, what “The Williams” is for Obstetrics and what the “The DSM-5” is for Psychiatry, “The Legato” is for Gender Medicine – an absolutely essential Must Have and Must Read for any professional who deals with the differences in physiology and pathophysiology between males and females.

Marek Glezerman, MD
Professor Emeritus of Obstetrics and Gynecology
Chairman of the Ethics Committee
Sackler School of Medicine
Tel Aviv University

The new Principles of Gender-Specific Medicine, edited by Dr. Marianne Legato from Columbia University, is a compilation of the most up-to-date topics in sex and gender difference research.  The chapters cover the major genomic, cellular, molecular and whole body “hot” topics in the field.  In addition, there are innovative pieces such as “Robots and Gender” by Tatsuya Nomura. Get this book and keep it on your shelf as a ready reference for state-of-the-art research in sex and gender differences that will inspire current and future scientists for years to come. 

Jane F. Reckelhoff, PhD
Billy S. Guyton Distinguished Professor
Chair, Department of Biochemistry
Director, Women’s Health Research Center
Director, Research Development, Office of Research and Sponsored Programs
University of Mississippi Medical Center
Jackson, MS

Marianne J. Legato (Author)
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Marianne J. Legato

Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. These enterprises are the first collaborations between academic medicine and the private sector focused solely on gender-specific medicine: the science of how normal human biology differs between men and women and of how the diagnosis and treatment of disease differs as a function of gender and sex. Her ground breaking textbook on Gender-and Sex Specific Medicine has been published in 2017 in the 3rd edition. She has published extensively on Gender and Sex Specific Medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the Journal Gender and Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine’s "Best Doctors" since the feature’s inception in 1993.