In 2017, the Academic Press released the third edition of our classic textbook, The Principles of Gender-Specific Medicine: Gender in the Genomic Era. Since then, it has won the PROSE Award in Clinical Medicine 2018 from the Association of American Pbulishers. A fourth edition of the textbook is forthcoming.
We published the first overview of what was then the new science of gender-specific medicine in 2004. The second edition was published in 2010. In the last two decades, gender-specific medicine has become firmly established and is the focus of basic science and clinical investigation worldwide. This edition reflects the scientific revolution of the 21st century and is a complete departure from the format of the first two editions of our textbook. Its contents showcase the innovative and cutting-edge technology of the genomic era as well as the potential power of synthetic biology and the increasing use of engineering to augment the performance of living beings.
Praise for Principles of Gender-Specific Medicine, 3rd edition
As much as the first edition of Principles of Gender-Specific Medicine defined the field of sex and gender health a decade ago, this third edition redefines it taking into account the evolution and complexity of genomic, hormonal and immunological science of sex differences. Marianne Legato uses an innovative approach to organizing cutting edge topics outside of the typical format of medical textbooks, which aids the reader in viewing the science in novel ways. Even for those working in the field of sex and gender based medicine, there is so much to learn from this rich collection of experts and content. Thank you once again Marianne Legato!
Alyson J. McGregor, MD, MA, FACEP
Director, Division of Sex and Gender in Emergency Medicine (SGEM)
Director, Sex and Gender in Emergency Medicine (SGEM) Fellowship
Associate Professor of Emergency Medicine
Warren Alpert Medical School of Brown University
The name Marianne Legato has become almost synonymous with Gender and Sex-specific Medicine. She was founder and Editor-in Chief of the first scientific journal dedicated to this new science (and has recently founded a new journal – “Gender and the Genome”). She was and is Editor-in-Chief of the first textbook on Gender Medicine, which appears now in the present third edition and she has been a scout in promoting Gender Medicine throughout the world. Her books have been eye-openers for many of us and this new edition of Principles of Gender-Specific Medicine is again a breakthrough. It includes carefully chosen contributions from leading scholars, researchers and clinicians from all over the globe, who present the state-of-the-art in their respective fields. What “The Harrison” is for Internal Medicine, what “The Williams” is for Obstetrics and what the “The DSM-5” is for Psychiatry, “The Legato” is for Gender Medicine – an absolutely essential Must Have and Must Read for any professional who deals with the differences in physiology and pathophysiology between males and females.
Marek Glezerman, MD
Professor Emeritus of Obstetrics and Gynecology
Chairman of the Ethics Committee
Sackler School of Medicine
Tel Aviv University
The new Principles of Gender-Specific Medicine, edited by Dr. Marianne Legato from Columbia University, is a compilation of the most up-to-date topics in sex and gender difference research. The chapters cover the major genomic, cellular, molecular and whole body “hot” topics in the field. In addition, there are innovative pieces such as “Robots and Gender” by Tatsuya Nomura. Get this book and keep it on your shelf as a ready reference for state-of-the-art research in sex and gender differences that will inspire current and future scientists for years to come.
Jane F. Reckelhoff, PhD
Billy S. Guyton Distinguished Professor
Chair, Department of Biochemistry
Director, Women’s Health Research Center
Director, Research Development, Office of Research and Sponsored Programs
University of Mississippi Medical Center
Marianne J. Legato (Author)
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Marianne J. Legato, MD, Ph. D. (hon. c.), FACP is an internationally renowned academic, physician, author, lecturer, and pioneer in the field of gender-specific medicine. She is a Professor Emerita of Clinical Medicine at Columbia University College of Physicians & Surgeons and an Adjunct Professor of Medicine at Johns Hopkins Medical School. Dr. Legato is also the Director of the Foundation for Gender-Specific Medicine, which she founded in 2006 as a continuation of her work with The Partnership for Gender-Specific Medicine at Columbia University. She received an honorary PhD from the University of Panama in 2015 for her work on the differences between men and women.
At its core, gender-specific medicine is the science of how normal human biology differs between men and women and how the diagnosis and treatment of disease differs as a function of gender. Dr. Legato’s discoveries and those of her colleagues have led to a personalization of medicine that assists doctors worldwide in understanding the difference in normal function of men and women and in their sex-specific experiences of the same diseases.
She began her work in gender-specific medicine by authoring the first book on women and heart disease, The Female Heart: The Truth About Women and Coronary Artery Disease, which won the Blakeslee Award of the American Heart Association in 1992. Because of this research, the cardiovascular community began to include women in clinical trials affirming the fact that the risk factors, symptoms, and treatment of the same disease can be significantly different between the sexes. Convinced that the sex-specific differences in coronary artery disease were not unique, Dr. Legato began a wide-ranging survey of all medical specialties and in 2004, published the first textbook on gender-specific medicine, The Principles of Gender-Specific Medicine. The second edition appeared in 2010 and the third edition, dedicated to explaining how gender impacts biomedical investigation in the genomic era, won the PROSE Award in Clinical Medicine from the Association of American Publishers in 2018. A fourth edition is forthcoming.
She also founded the first scientific journals publishing new studies in the field, The Journal of Gender-Specific Medicine, and a newer version, Gender Medicine, both listed in the Index Medicus of the National Library of Medicine. She has founded a third peer-reviewed, open access journal, Gender and the Genome, which focuses on the impact of biological sex on technology and its effects on human life.
Dr. Legato is the author of multiple works, including: What Women Need to Know (Simon & Schuster, 1997), Eve’s Rib (Harmony Books, 2002), Why Men Never Remember and Women Never Forget (Rodale, 2005), Why Men Die First (Palgrave, 2008), The International Society for Gender Medicine: History and Highlights (Academic Press, 2017), and most recently, The Plasticity of Sex (Academic Press, 2020). Her books have been translated into 28 languages to date.
As an internationally respected authority on gender medicine, Dr. Legato has chaired symposia and made keynote addresses to world congresses in gender-specific medicine in Berlin, Israel, Italy, Japan, Panama, South Korea, Stockholm, and Vienna. In collaboration with the Menarini Foundation, she is co-chairing a symposium on epigenetics, Sex, Gender and Epigenetics: From Molecule to Bedside, to be held in Spring 2021 in Italy. She maintains one of the only gender-specific private practice in New York City, and she has earned recognition as one of the “Top Doctors in New York.”