2012 Awardee, Johns Hopkins
Dr. Kendall Moseley, Assistant Professor of Medicine, has set out to demystify sex-specific differences in bone quality in men and women with type 2 diabetes mellitus (T2DM). Despite high bone mineral density (BMD), persons with T2DM are at increased risk for hip fracture compared to those without diabetes. Hip geometry is one measure of bone quality that has not been evaluated in men and women with T2DM. Insufficient hip geometry, or how bones withstand outside bending and crushing forces, could cause men or women to be at higher risk for fracture. Dr. Moseley and her team suspect that with worsening glucose control, hip geometry measurements of bone quality decline despite good bone density. Moreover, they suspect there are important gender differences in the hip geometry of men and women with T2DM that could make one group at greater fracture risk as blood glucose soars out of control.