SIGN IN YOUR ACCOUNT TO HAVE ACCESS TO DIFFERENT FEATURES

FORGOT YOUR PASSWORD?

FORGOT YOUR DETAILS?

AAH, WAIT, I REMEMBER NOW!
MENUMENU
  • DR. LEGATO
    • Scientific Bio
    • Curriculum Vitae
    • Gender Medicine Editorials
    • Selected Articles
  • ABOUT US
    • Just The Facts
    • Our Logo
    • Our Team
    • Our Goals
    • Our Mission
  • ABOUT GSM
    • Suggested Reading
    • Men’s Health
    • Women’s Health
  • PUBLICATIONS
    • Journal
    • Scientific Publications
  • LOGIN

The Foundation For Gender-Specific Medicine

MENUMENU
  • Home
  • Grants
  • Blog
  • News
  • Events
  • Books
  • Gala
  • Find A Doctor
  • Board Of Directors
  • Contact Us
DONATE
  • Home
  • blog
  • Dr. Legato's Blog
  • “Revisiting the Flight of Icarus: Making Human Organs from PSCs with Large Animal Chimeras” – Discussion
February 24, 2021

“Revisiting the Flight of Icarus: Making Human Organs from PSCs with Large Animal Chimeras” – Discussion

“Revisiting the Flight of Icarus: Making Human Organs from PSCs with Large Animal Chimeras” – Discussion

by Jordan Musante / Monday, 26 August 2019 / Published in Dr. Legato's Blog

Pluripotent stem cells, also known as “master” cells, have the ability to divide into all three types of body layers in humans – the ectoderm (skin and nervous system), the endoderm (endocrine glands, liver, pancreas, respiratory and gastrointestinal tracts), and the mesoderm (bone, muscle, cartilage, circulatory system and connective tissues.) These “master cells” have the ability to continuously self-generate, granting them nearly infinite potential to be born anew. Scientists are tapping into this potential for a multitude of biomedical advances, including our ability to synthetically grow what are called “organ niches.”

Embryonic development of mature human organs is very intricate, and many limitations exist when attempting to replicate such complexities. Because of the high demand for organ donation and limited number of donors, scientists are searching for technological solutions to bridge this gap. Researcher Hiromitsu Nakauchi of Stanford University has begun to develop these “organ niches” – human pluripotent stem cells planted inside animal embryos and grown to adulthood within animal hosts. The animal hosts, also known as “animal chimeras,” bear semblance to the story of Icrarus in Greek mythology; Icarus constructed bird-like wings to defy the inhibitions of his human body. Mice, pigs, and other animals are being utilized to create “clinically useful end products” using the induced stem cells, in hopes of increasing positive outcomes for human patients with end-stage organ failure.

The chimeras, while not yet advanced enough to produce fully-functioning, human-like organs which operate independently, will eventually be utilized in both toxicology studies and disease models, as well as therapeutic ones. The potential for this new technology is, just like the pluripotent stem cells themselves, nearly infinite. While tethering human and animal physiology is an exciting new frontier, we may be tapping into a chasm of possibility that could expand beyond our control. It begs the question – Will researchers of the future utilize interspecies chimera generation in a responsible way, or are we flying too close to the sun?

Link to article: https://www.sciencedirect.com/science/article/pii/S1934590914004044

Facebook Comments
Avatar
Jordan Musante
0
SHARES
ShareTweet

What you can read next

shadow of Couple kissing
The End of a Romantic Relationship is Truly Agonizing
cartoon character having hot drink
The Flu Shot: ?Effective ?Dangerous ? Worth the Trouble?
Summer and smoke
Summer and Smoke

Subscribe to receive Dr. Legato's weekly newsletter.

From Dr. Legato’s Blog

  • Pregnancy During the Pandemic: What’s lost when women are left out
  • COVID-19 Update: When is a vaccine coming?  How effective will it be?
  • Varicose Veins
  • Split Ends Split Ends
  • Are Hair Dyes Safe?
  • Fainting
  • I wear an underwire bra, am I increasing my risk of cancer? breast pimple illustration
  • When Your Plastic Heart Changes It’s Structure and Function to Produce What You Need Doctors stethoscope
  • Does Drinking Wine Prevent Heart Attacks? People hands with wine glasses
  • Ravages Of The Covid Pandemic
  • ​Memorial For Harold Burson With Great Sadness
  • Online Video Medical Consultation Clinic waiting room
  • Vaginal Deodorants Vaginal Deodorants bottle
  • Exercise Exercise for an active life
  • Douching douching for a better hygiene
  • Doctors Doctors in operation
  • Death and Dying Holding hands
  • Digestive Disorders women suffering from Digestive Disorders
  • Antibiotics and Birth Control Pills Image of antibiotic pills
  • The Morning After Pill Women having a cup of hot drink

Scientific Publications

  • Principles of Gender-Specific Medicine, Third Edition: Gender in the Genomic Era
    Foundation Gala
  • Principles Of Gender-Specific Medicine
    Principles Of Gender-Specific Medicine
  • PRINCIPLES OF GENDER-SPECIFIC MEDICINE TEXTBOOK
    PRINCIPLES OF GENDER-SPECIFIC MEDICINE TEXTBOOK

Our Partners

Partnering with the best in the industry

Stay connected

Submit your email and join our weekly newsletter to stay up-to-date with the Foundation.

Main Menu
  • Home
  • Grants
  • Blog
  • News
  • Events
  • Books
  • Gala
  • Find A Doctor
  • Board Of Directors
  • Contact Us
About Dr. Legato
  • Dr. Legato
  • Curriculum Vitae
  • Scientific Bio
  • Gender Medicine Editorials
  • Selected Articles
About Us
  • About us
  • Our Mission
  • Our Goals
  • Our Team
  • Our Logo
About GSM
  • About GSM
  • Just The Facts
  • Women’s Health
  • Men’s Health
  • Suggested Reading
  • Site Map
  • Privacy Policy

© 2020 All rights reserved www.gendermed.org Developed and powered by www.SlideSigma.com

TOP
MENU
  • DR. LEGATO
    • Scientific Bio
    • Curriculum Vitae
    • Gender Medicine Editorials
    • Selected Articles
  • ABOUT US
    • Just The Facts
    • Our Logo
    • Our Team
    • Our Goals
    • Our Mission
  • ABOUT GSM
    • Suggested Reading
    • Men’s Health
    • Women’s Health
  • PUBLICATIONS
    • Journal
    • Scientific Publications