Science and Legal Experts Debate Future Uses and Impact of Human Genome Editing in Gender and the Genome
New Rochelle, NY, December 13, 2016—Precise, economical genome editing tools such as CRISPR have made it possible to make targeted changes in genes, which could be applied to human embryos to correct mutations, prevent disease, or alter traits. A panel of experts discusses the controversies related to the possibility of editing the human embryonic genome and creating man-made modifications that would be passed on to future generations, in a Roundtable Discussion published in Gender and the Genome, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Journal Editor-in-Chief Marianne Legato, MD, PhD (hon. c.), FACP, Columbia University (New York, NY) moderated a lively and insightful discussion among distinguished panelists George Church, PhD, Harvard University and Massachusetts Institute of Technology (Cambridge, MA), Henry Greely, JD, Stanford University School of Law (CA), Tetsuya Ishii, PhD, Hokkaido University (Japan), Virginia Miller, PhD, Mayo Clinic (Rochester, MN), and Justin Killian, Esq and Sherif Moussa, Esq, both from Foundation for Gender-Specific Medicine (New York, NY).
The Roundtable Discussion is entitled “Editing the Human Genome: Progress and Controversies.”
Among the scientific, societal, and legal implications of a future in which we may be able to modify the genetic makeup of human embryos, the Roundtable panelists discussed what a “balanced regulatory approach” to oversee the use of genome editing tools might look like, potential safety issues, the concept of using genome editing to make cosmetic choices for a prospective child, and the legal implications of parents’ rights to manipulate the genome of an embryo.
“Our ability to manipulate the human genome is a paradigm shift that trumps Darwinian evolution,” says Dr. Legato.
About the Journal ( Click here to know more About Journal )
Gender and the Genome, published quarterly in print and online, will feature evidence-based original research, reviews, perspectives, and commentaries that will illuminate the impact of biological sex on 21st century technology and its effect on human life. The international editorial board will include the most forward-thinking leaders in gender-specific medicine to engage the community of molecular biologists, engineers, ethicists, anthropologists, and legal experts engaged in a dialogue about the nature and implications of 21st century technology.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including DNA and Cell Biology, Human Gene Therapy, Nucleic Acid Therapeutics, and Cellular Reprogramming. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
About the Foundation for Gender-Specific Medicine
The Foundation for Gender Specific-Medicine supports the investigation of the ways in which biological sex and gender affect normal human function and the experience of disease. One of the discipline’s pioneers, Marianne J. Legato, MD, PhD (hon. c.), FACP, established the Foundation as a continuation of her work with The Partnership for Gender-Specific Medicine at Columbia University.
Marianne J. Legato, MD, Ph. D. (hon. c.), FACP is an internationally renowned academic, physician, author, lecturer, and pioneer in the field of gender-specific medicine. She is a Professor Emerita of Clinical Medicine at Columbia University College of Physicians & Surgeons and an Adjunct Professor of Medicine at Johns Hopkins Medical School. Dr. Legato is also the Director of the Foundation for Gender-Specific Medicine, which she founded in 2006 as a continuation of her work with The Partnership for Gender-Specific Medicine at Columbia University. She received an honorary PhD from the University of Panama in 2015 for her work on the differences between men and women.
At its core, gender-specific medicine is the science of how normal human biology differs between men and women and how the diagnosis and treatment of disease differs as a function of gender. Dr. Legato’s discoveries and those of her colleagues have led to a personalization of medicine that assists doctors worldwide in understanding the difference in normal function of men and women and in their sex-specific experiences of the same diseases.
She began her work in gender-specific medicine by authoring the first book on women and heart disease, The Female Heart: The Truth About Women and Coronary Artery Disease, which won the Blakeslee Award of the American Heart Association in 1992. Because of this research, the cardiovascular community began to include women in clinical trials affirming the fact that the risk factors, symptoms, and treatment of the same disease can be significantly different between the sexes. Convinced that the sex-specific differences in coronary artery disease were not unique, Dr. Legato began a wide-ranging survey of all medical specialties and in 2004, published the first textbook on gender-specific medicine, The Principles of Gender-Specific Medicine. The second edition appeared in 2010 and the third edition, dedicated to explaining how gender impacts biomedical investigation in the genomic era, won the PROSE Award in Clinical Medicine from the Association of American Publishers in 2018. A fourth edition is forthcoming.
She also founded the first scientific journals publishing new studies in the field, The Journal of Gender-Specific Medicine, and a newer version, Gender Medicine, both listed in the Index Medicus of the National Library of Medicine. She has founded a third peer-reviewed, open access journal, Gender and the Genome, which focuses on the impact of biological sex on technology and its effects on human life.
Dr. Legato is the author of multiple works, including: What Women Need to Know (Simon & Schuster, 1997), Eve’s Rib (Harmony Books, 2002), Why Men Never Remember and Women Never Forget (Rodale, 2005), Why Men Die First (Palgrave, 2008), The International Society for Gender Medicine: History and Highlights (Academic Press, 2017), and most recently, The Plasticity of Sex (Academic Press, 2020). Her books have been translated into 28 languages to date.
As an internationally respected authority on gender medicine, Dr. Legato has chaired symposia and made keynote addresses to world congresses in gender-specific medicine in Berlin, Israel, Italy, Japan, Panama, South Korea, Stockholm, and Vienna. In collaboration with the Menarini Foundation, she is co-chairing a symposium on epigenetics, Sex, Gender and Epigenetics: From Molecule to Bedside, to be held in Spring 2021 in Italy. She maintains one of the only gender-specific private practice in New York City, and she has earned recognition as one of the “Top Doctors in New York.”