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Marianne J. Legato
Friday, 04 December 2020 / Published in Events

Comments on the importance of alerting the public to side effects from both the Pfizer and Moderna vaccines

This week’s issue of Science magazine* comments on the importance of alerting the public to side effects from both the Pfizer and Moderna vaccines; most are transient (about 12 hours in duration) and bearable  but some people will experience more severe side effects: Moderna reported fatigue in 9.7% , muscle pain in 8.9%, joint pain in 5.2% and headache in 4.5% of patients. The Pfizer report of severe side effects was not as intense:  fatigue in 3.8% and headache in 2%. Both vaccines require two doses; the second dose will most probably provoke a more intense reaction than the first.
While the vaccine will abort the severity of this pandemic, the public should anticipate and be prepared for side effects which might be severe in 2-10% of individuals. Covid infection is potentially considerably worse than the transient consequences of immunization, so vaccination is crucially important, but the public needs to have transparency about what to expect on a short-term basis.
*Wadman M. Public needs to prep for vaccine side effects. New in Depth.Science 370:issue 6520, p.1022.
Marianne J. Legato
Marianne J. Legato

Marianne J. Legato, MD, Ph. D. (hon. c.), FACP is an internationally renowned academic, physician, author, lecturer, and pioneer in the field of gender-specific medicine. She is a Professor Emerita of Clinical Medicine at Columbia University College of Physicians & Surgeons and an Adjunct Professor of Medicine at Johns Hopkins Medical School. Dr. Legato is also the Director of the Foundation for Gender-Specific Medicine, which she founded in 2006 as a continuation of her work with The Partnership for Gender-Specific Medicine at Columbia University. She received an honorary PhD from the University of Panama in 2015 for her work on the differences between men and women.

At its core, gender-specific medicine is the science of how normal human biology differs between men and women and how the diagnosis and treatment of disease differs as a function of gender. Dr. Legato’s discoveries and those of her colleagues have led to a personalization of medicine that assists doctors worldwide in understanding the difference in normal function of men and women and in their sex-specific experiences of the same diseases.

She began her work in gender-specific medicine by authoring the first book on women and heart disease, The Female Heart: The Truth About Women and Coronary Artery Disease, which won the Blakeslee Award of the American Heart Association in 1992. Because of this research, the cardiovascular community began to include women in clinical trials affirming the fact that the risk factors, symptoms, and treatment of the same disease can be significantly different between the sexes. Convinced that the sex-specific differences in coronary artery disease were not unique, Dr. Legato began a wide-ranging survey of all medical specialties and in 2004, published the first textbook on gender-specific medicine, The Principles of Gender-Specific Medicine. The second edition appeared in 2010 and the third edition, dedicated to explaining how gender impacts biomedical investigation in the genomic era, won the PROSE Award in Clinical Medicine from the Association of American Publishers in 2018. A fourth edition is forthcoming.

She also founded the first scientific journals publishing new studies in the field, The Journal of Gender-Specific Medicine, and a newer version, Gender Medicine, both listed in the Index Medicus of the National Library of Medicine. She has founded a third peer-reviewed, open access journal, Gender and the Genome, which focuses on the impact of biological sex on technology and its effects on human life.

Dr. Legato is the author of multiple works, including: What Women Need to Know (Simon & Schuster, 1997), Eve’s Rib (Harmony Books, 2002), Why Men Never Remember and Women Never Forget (Rodale, 2005), Why Men Die First (Palgrave, 2008), The International Society for Gender Medicine: History and Highlights (Academic Press, 2017), and most recently, The Plasticity of Sex (Academic Press, 2020). Her books have been translated into 28 languages to date.

As an internationally respected authority on gender medicine, Dr. Legato has chaired symposia and made keynote addresses to world congresses in gender-specific medicine in Berlin, Israel, Italy, Japan, Panama, South Korea, Stockholm, and Vienna. In collaboration with the Menarini Foundation, she is co-chairing a symposium on epigenetics, Sex, Gender and Epigenetics: From Molecule to Bedside, to be held in Spring 2021 in Italy. She maintains one of the only gender-specific private practice in New York City, and she has earned recognition as one of the “Top Doctors in New York.”

What you can read next

The Foundation For Gender-Specific Medicine
Workshop on Female Sex and Gender in Lunch/Sleep Health and Disease – National Heart, Lung, and Blood Institute & Office of Research on Women’s Health 2017
Women’s eNews’ 21 Leaders for the 21st Century Award Ceremony - May 2016
Women’s eNews’ 21 Leaders for the 21st Century Award Ceremony – May 2016
Honorees Causa Ceremony Panama Dec. 2015
Honoris Causa Ceremony Panama Dec. 2015

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